The number of road crashes, fatalities and injuries is considered unacceptably high in many countries. Risks in road traffic are far more higher than in other modes of transport. Road crashes are tragedies at a personal level and economic costs for society are considerable. A lot of knowledge has been gained over the years on causes of crashes and on risk factors. Our understanding of the effectiveness and efficiency of interventions to reduce risks has grown and implementation resulted in lower risks and less casualties. Fitting in a Safe System approach many promising options can further improve road safety.